Accurate Pyrogen Testing Without Animal Cruelty
Detect a broader range of pyrogens through MAT Research’s highly reliable Monocyte Activation Test. Rabbit Pyrogen Tests belong to the past.
Rabbit-Free Testing of a Broader Range of Pyrogens.
MAT Research offers a ready-to-use kit for the Monocyte Activation Test (MAT). The MAT is a rabbit-free alternative to the Rabbit Pyrogen Test (RPT) and can be used to test parenteral drugs for endotoxin and non-endotoxin contaminations. It mimics the human fever reaction to pyrogens by using cryopreserved human monocytes, ensuring it’s highly reliable and robust.
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Pyrogens — What They Are and Why We Should Care
Pyrogens are tiny particles that cause an immune response and thus induce fever when they are injected into the human body. Those particles derive from bacteria, viruses, fungi, or chemical substances and are heat resistant and very difficult to remove. Therefore even a sterile product can contain pyrogens that accidentally enter the product during production. Due to pyrogens’ adverse effects, pyrogen testing is essential in producing pharmaceutical products.
Pyrogen Testing for Batch Release
There is always a chance that batches are contaminated with pyrogens during production.
Product Specific Validation
For each product, possible interference with the MAT must be eliminated before testing with MAT.
Outsource Pyrogen Testing
Pyrogens are an inconvenient topic. Lean back and let us handle your pyrogen testing.
Which Drugs Have to Be Tested on Pyrogens?
In general, every parenteral drug has to be tested on pyrogens. Parenteral means that the drug is not taken orally but is injected. To be sure that no pyrogen contamination occurs, every batch of a parenteral drug has to be tested on pyrogens before its release. There exist four standard used methods for pyrogen testing, namely the Limulus Amebocyte Lysate test (LAL), the Monocyte Activation Test (MAT), the Rabbit Pyrogen Test (RPT), and the Recombinant Factor C test (rFC).
Developing the Mat, We Had to Overcome Many Obstacles.
But many years of Research and development made it possible to find solutions for many of those problems. Nonetheless, every MAT uses a slightly different technology; click here to learn more about the different types of MATs.
Keep Your Patients Safe
The Monocyte Activation Test saves rabbit lives. But what about human health?
Broader Range
Detect a broader range of pyrogens, including endotoxins and non-endotoxins.
Human Cells
Based on human pyrogen response, monocytes deliver highly reliable test results.
Higher Sensitivity
Higher test-sensitivity ensures safer and cleaner drugs.
Why Use Mat Research’s Technology?
There are several versions within MAT technology as well. Here are a few reasons our technology is one of the most sophisticated. But convince yourself you can find more information about different MAT technologies here.
Cryopreserved PBMC
For the best results, we use cryopreserved human monocytes.
Masters of Logistics
We ship our cells and our MAT kits within and outside Europe.
Unique R&D
With MAT Research, you are on top of technology, receiving the best on the market.
Patented Technologies
Our patented Auto MATR™ robot allows you to take your pyrogen testing to the next efficiency level.
Trusted by Leading Companies
Who We Are
We are a BioTech Company from Leiden, the Netherlands, specialising in MAT tests. Meet the faces behind MAT Research.
Pyrogens
Pyrogens are a pretty complex topic. Therefore we try to provide you with all you have to know to find your perfect solution.
Our Service
How we can help you to perform pyrogen test. Check out our services here.
Contact Us
We would love to be able to answer your questions and discuss how we can contribute to improving your pyrogen testing.
Ready to Face the Future
The European pharmacopeia announced the prohibition of rabbit tests by 2026. Since the Rabbit Pyrogen Test is the only test on the market that detects all kinds of pyrogens, the Monocyte Activation Test is the superior suitable substitute.
Our Laboratory in Leiden Bioscience Park Netherlands
