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Accurate Pyrogen Testing Without Animal Cruelty

Detect a broader range of pyrogens through MAT Research’s highly reliable Monocyte Activation Test. Rabbit Pyrogen Tests belong to the past.

Rabbit-Free Testing of a Broader Range of Pyrogens.

MAT Research offers a ready-to-use kit for the Monocyte Activation Test (MAT). The MAT is a rabbit-free alternative to the Rabbit Pyrogen Test (RPT) and can be used to test parenteral drugs for endotoxin and non-endotoxin contaminations. It mimics the human fever reaction to pyrogens by using cryopreserved human monocytes, ensuring it’s highly reliable and robust.

Quality You Can Rely On

We’re ISO:9001:2015 Certified to ensure the highest levels of quality for our products and services.

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Pyrogens — What They Are and Why We Should Care

Pyrogens are tiny particles that cause a fever-inducing immune response when injected into the human body. They derive from bacteria, viruses, fungi, or chemical substances, are heat resistant, and very difficult to remove. Even a sterile product can contain pyrogens. Due to pyrogens’ adverse effects, pyrogen testing is essential in producing pharmaceutical products. 

Glass bottles in production in the tray of an automatic liquid dispenser, a line for filling medicines against bacteria and viruses, antibiotics and vaccines

Pyrogen Testing for Batch Release

There is always a chance that batches are contaminated with pyrogens during production.

MAT for batch release →

MAT Research performs Product Specific Validation tests

Product Specific Validation

For each product, possible interference with the MAT must be eliminated before testing with MAT.

Validation services →

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Outsource Pyrogen Testing

Pyrogens are an inconvenient topic. Lean back and let us handle your pyrogen testing.

Outsourcing services →

Vaccination of senior person in hospital. Parenteral drugs must be tested for pyrogens.

Which Drugs Have to Be Tested on Pyrogens?

In general, every parenteral drug has to be tested on pyrogens. Parenteral means that the drug is not taken orally but is injected. To be sure that no pyrogen contamination occurs, every batch of a parenteral drug has to be tested on pyrogens before its release. There exist four standard used methods for pyrogen testing, namely the Limulus Amebocyte Lysate test (LAL), the Monocyte Activation Test (MAT), the Rabbit Pyrogen Test (RPT), and the Recombinant Factor C test (rFC).

Scientists at MAT Research Lab

Developing the Mat, We Had to Overcome Many Obstacles.

But many years of Research and development made it possible to find solutions for many of those problems. Nonetheless, every MAT uses a slightly different technology; click here to learn more about the different types of MATs.

Keep Your Patients Safe

The Monocyte Activation Test saves rabbit lives. But what about human health?

Broader Range​

Detect a broader range of pyrogens, including ­endotoxins and non-endotoxins.

Human Cells

Based on human pyrogen response, monocytes deliver highly reliable test results.

Higher Sensitivity

Higher test-sensitivity ensures safer and cleaner drugs.

Scientist operating the AutoMATr. A MAT automation robot by MAT Research.

Why Use Mat Research’s Technology?

There are several versions within MAT technology as well. Here are a few reasons our technology is one of the most sophisticated. But convince yourself you can find more information about different MAT technologies here.

Cryopreserved PBMC

For the best results, we use cryopreserved human monocytes.

Masters of Logistics

We ship our cells and our MAT kits within and outside Europe.

Unique R&D

With MAT Research, you are on top of technology, receiving the best on the market.

Patented Technologies

Our patented Auto MATR™ robot allows you to take your pyrogen testing to the next efficiency level.

Trusted by Leading Companies

Who We Are

We are a BioTech Company from Leiden, the Netherlands, specialising in MAT tests. Meet the faces behind MAT Research.

About us →


Pyrogens are a pretty complex topic. Therefore we try to provide you with all you have to know to find your perfect solution.

Learn about pyrogen →

Our Service

How we can help you to perform pyrogen test. Check out our services here.

Our services →

Contact Us

We would love to be able to answer your questions and discuss how we can contribute to improving your pyrogen testing. 

Reach out →

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Ready to Face the Future

The European pharmacopeia announced the prohibition of rabbit tests by 2026. Since the Rabbit Pyrogen Test is the only test on the market that detects all kinds of pyrogens, the Monocyte Activation Test is the superior suitable substitute.

Our Laboratory in Leiden Bioscience Park Netherlands

Scientists at MAT Research Lab
MAT Research Services Automatr robot to perform MAT.
Scientist working in the MAT Research lab.